GPR: 2021 - Week 31

From MGH Learn Pathology

Clinical history

45 year-old male with chest discomfort found to have a 7cm, multilobulated, heterogeneous anterior mediastinal mass.


GPR21-23-e87a6784-dfe6-4613-8768-8db920ae9f7d.jpeg


Registered users must be logged in to access the interactive quiz.


GPR21-23-e87a6784-dfe6-4613-8768-8db920ae9f7d.jpeg

 
Thymic Carcinoma (SCC)
  • Frankly invasive
  • Hard, tan cut surface
  • Foci of hemorrhage and necrosis are common
  • Most commonly in 6th decade, and slightly more often in men
 

GPR21-23-a16d9cf2-d1e5-4c60-8308-56a267cc5b3b.jpeg

 

Thymoma

  • Encapsulated with adjacent normal thymus
  • Firm, grey-pink to yellow-tan cut surface
  • Solid, nodular surface with white fibrous bands; may appear heterogeneous due to spindled (Type A) and lymphocyte-rich (type B) components
  • Most common in 5th & 6th decades, slight female predominance
 

GPR21-23-dc727565-4b19-4c51-b34e-aa6bfff9c473.jpeg

 

Mature Cystic Teratoma

  • Can occur at any age
  • Encapsulated
  • Heterogenous, cystic cut surface
  • Cyst contents include: keratinaceous debris, hair, fat (cartilage, teeth, bone)
 

GPR21-23-36bf04f3-1b16-4d48-a319-404d8f43dea8.jpeg

 

Yolk Sac Tumor

  • Soft, solid mass
  • Pale grey to grey-white cut surface
  • Gelatinous or mucoid quality
  • May have hemorrhage or necrosis following neo-adjuvant treatment
  • Uncommon, peak in the third decade
  • Nearly all in males
 
  • Jessica Botelho Houston
  • Mike Marshall
  • Kara Tassinari
  • Stefanie Flores
  • Robert Hasserjian

This week's Gross Pathology Roundup was presented by Caroline Hilburn MD on 2021-08-02.