GPR: 2021 - Week 31

From MGH Learn Pathology

Clinical history

45 year-old male with chest discomfort found to have a 7cm, multilobulated, heterogeneous anterior mediastinal mass.


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Thymic Carcinoma (SCC)
  • Frankly invasive
  • Hard, tan cut surface
  • Foci of hemorrhage and necrosis are common
  • Most commonly in 6th decade, and slightly more often in men




  • Encapsulated with adjacent normal thymus
  • Firm, grey-pink to yellow-tan cut surface
  • Solid, nodular surface with white fibrous bands; may appear heterogeneous due to spindled (Type A) and lymphocyte-rich (type B) components
  • Most common in 5th & 6th decades, slight female predominance



Mature Cystic Teratoma

  • Can occur at any age
  • Encapsulated
  • Heterogenous, cystic cut surface
  • Cyst contents include: keratinaceous debris, hair, fat (cartilage, teeth, bone)



Yolk Sac Tumor

  • Soft, solid mass
  • Pale grey to grey-white cut surface
  • Gelatinous or mucoid quality
  • May have hemorrhage or necrosis following neo-adjuvant treatment
  • Uncommon, peak in the third decade
  • Nearly all in males
  • Jessica Botelho Houston
  • Mike Marshall
  • Kara Tassinari
  • Stefanie Flores
  • Robert Hasserjian

This week's Gross Pathology Roundup was presented by Caroline Hilburn MD on 2021-08-02.