GPR: 2021 - Week 24

From MGH Learn Pathology

Clinical history

14 year-old female with an incidentally identified, unilateral, 3.6 cm adrenal lesion.


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Mature ganglioneuroma
  • Well-defined with smooth, fibrous capsule
  • Cut surface is grey-white or pale yellow
  • Calcifications
  • No hemorrhage or necrosis



Adrenal cortical adenoma

  • Usually unilateral and solitary
  • Well-circumscribed, golden yellow on cross section
  • Atrophy of the uninvolved cortex




  • Cut surface is pink-grey to tan
  • May have hemorrhage or necrosis
  • Frequently associated with hereditary disease



Adrenal cortical hyperplasia

  • Bilateral, diffuse cortical expansion
  • Cortical thickening with streaks of yellow and brown
  • May be nodular and/or pigmented
  • Kristine Cornejo, MD

This week's Gross Pathology Roundup was presented by Caroline Hilburn, MD on Mon, Jun 14, 2021.