GPR: 2020 - Week 30
Clinical history
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Tubulocystic Renal Cell Carcinoma -Rare kidney tumor featuring tubular and cystic architectural growth
-Well-circumscribed, unifocal -Spongy “bubble wrap” appearance -Variable-sized cysts contain clear serous fluid -Range: 0.2-17 cm (4.2 cm average) -Recurrent losses at ch 9 and gains at ch 17 |
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Multilocular Cystic Clear Cell Renal Cell Neoplasm of Low Malignant Potential -Renal neoplasm composed of clear cell-lined cysts
-Well circumscribed, often with fibrous pseudocapsule -Marked variation in cyst size -No solid or expansile masses are present in tumor |
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Clear Cell Renal Cell Carcinoma with cystic change -Typically show golden-yellow cut surfaces
-Areas featuring necrosis, fibrosis, cystic change, hemorrhage are common -Some cases show prominent cystic changes. Extensive sampling to identify solid may be required |
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Cystic Nephroma -In adults, considered to be within the mixed epithelial and stromal tumor family
-Pediatric lesions: associated with DICER1 gene mutations -Well circumscribed with a capsule -Diffusely cystic with clear serous fluid contents -Solid areas may represent sarcomatous transformation |
This week's Gross Pathology Roundup was presented by Lucas Massoth, MD on Mon, Jul 20, 2020.
