GPR: 2021 - Week 01

• GPR Quiz
• Answer
• DDx1
• DDx2
• DDx3
• Acknowledgments
• Reference(s)

Clinical history

29 year old male with firm, irregular testicular mass.

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Embryonal carcinoma 15-35 y/o (generally younger population than seminoma) 2nd most common pure testicular germ cell neoplasm, but more often a component of malignant mixed germ cell tumor fleshy gray and white with variegated appearance prominent necrosis and hemorrhage

Seminoma 35-45 y/o most common malignant testicular neoplasm Well circumscribed and homogeneous with or without lobulation gray-white, tan, creamy, often bulging cut surface usually no hemorrhage or necrosis

Leydig cell tumor 2 peaks: 5-10 y/o and 30-35 y/o most common sex cord-stromal testicular neoplasm, but rare overall (1-3% of total testicular neoplasms) well-circumscribed, intraparenchymal nodule yellow-tan homogeneous or lobulated cut surface; lobules may be separated by fibrous bands necrosis and hemorrhage are uncommon

Diffuse large B-cell lymphoma (primary testicular lymphoma) most common testicular neoplasm in >60 y/o rare, 1% of all non-Hodgkins lymphomas in the US DLBCL is most common primary testicular lymphoma large (median: ~6 cm), fleshy, homogeneous mass

• Jakob Moran
• Himanshu Gunderia
• Derek Kingman

ExpertPath

WebPathology

Chan Y. Cheah, Andrew Wirth, John F. Seymour; Primary testicular lymphoma. Blood 2014; 123 (4): 486–493. doi: https://doi.org/10.1182/blood-2013-10-530659

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This week's Gross Pathology Roundup was presented by Miranda Machacek MD, PhD on 2021-01-04.