GPR: 2020 - Week 47
From MGH Learn Pathology
62 year old male, former beach lifeguard for 25 years, presents with new large growth on his back.
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TERT Promoter mutations
A 2017 Nature paper that conducted whole genome sequencing on 183 melanoma samples found 86% of cutaneous melanomas were mutated at 1 of 4 TERT promoter sites.
RAS family mutation
30-35% of melanomas contain mutations in RAS family member genes
- Dr. Jochen Lennerz for conceptual inspiration
- Dr. T. Leif Helland for gross image
- Hayward, N., Wilmott, J., Waddell, N. et al. Whole-genome landscapes of major melanoma subtypes. Nature 545, 175–180 (2017). https://doi.org/10.1038/nature22071
- The Cancer Genome Atlas Network. Genomic Classification of Cutaneous Melanoma. Cell 161(7): 1681–1696 (2015). https://dx.doi.org/10.1016%2Fj.cell.2015.05.044
This week's Gross Pathology Roundup was presented by Tyler Miller MD, PhD on 2020-11-16.