GPR: 2020 - Week 36

From MGH Learn Pathology

Clinical history

84-year-old woman with an enlarging 7.5 cm cystic mass in the head of the pancreas


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Serous cystadenoma
  • Most commonly in females patients around age 50
  • Well-demarcated lesion composed of numerous thin-walled microcysts filled with serous fluid
  • Can be multifocal
  • Occurs anywhere in the pancreas
  • Often with stellate scar(s)



Mucinous cystic neoplasm (MCN)

  • Found in female patients
  • Solitary, multilocular cyst with thin, opaque septa and mucinous fluid
  • Most often in the pancreatic body/tail
  • Does not communicate with the main pancreatic duct or side branches



Intraductal papillary mucinous neoplasm (IPMN)

  • Common; often incidentally found in men and women in their 60s
  • Cystic lesion arising from main pancreatic duct or branch duct, filled with mucinous fluid
  • Cyst lining may be smooth (commonly branch ducts) or papillary (commonly main duct)
  • Can be multifocal
  • Most often in pancreatic head



Pancreatic neuroendocrine tumor (PanNET)

  • Found in male and female patients 30-60 years old
  • Well-demarcated round tan/mahogany lesion
  • ~5% are cystic and filled with serous fluid
  • Dr. Rory Crotty
  • Dr. Jakob Moran

This week's Gross Pathology Roundup was presented by Bailey Hutchison, MD on Mon, Aug 31, 2020.