GPR: 2020 - Week 36

• GPR Quiz
• Answer
• DDx1
• DDx2
• DDx3
• Acknowledgments

Clinical history

84-year-old woman with an enlarging 7.5 cm cystic mass in the head of the pancreas

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Serous cystadenoma Most commonly in females patients around age 50 Well-demarcated lesion composed of numerous thin-walled microcysts filled with serous fluid Can be multifocal Occurs anywhere in the pancreas Often with stellate scar(s)

Mucinous cystic neoplasm (MCN) Found in female patients Solitary, multilocular cyst with thin, opaque septa and mucinous fluid Most often in the pancreatic body/tail Does not communicate with the main pancreatic duct or side branches

Intraductal papillary mucinous neoplasm (IPMN) Common; often incidentally found in men and women in their 60s Cystic lesion arising from main pancreatic duct or branch duct, filled with mucinous fluid Cyst lining may be smooth (commonly branch ducts) or papillary (commonly main duct) Can be multifocal Most often in pancreatic head

Pancreatic neuroendocrine tumor (PanNET) Found in male and female patients 30-60 years old Well-demarcated round tan/mahogany lesion ~5% are cystic and filled with serous fluid

• Dr. Rory Crotty
• Dr. Jakob Moran

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This week's Gross Pathology Roundup was presented by Bailey Hutchison, MD on Mon, Aug 31, 2020.