GPR: 2019 - Week 47

From MGH Learn Pathology

Clinical history

38 yo G3P1011 s/p RCS at 39w1d. 3.0 cm tan-white solid-cystic nodule within the placental membranes.

GPR19-38 -Placental Nodule Gross.JPG

GPR19-38 -Placental Nodule Cross Section.JPG

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GPR19-38 -Placental Nodule Gross.JPG

Mature Cystic Teratoma
  • At least 2 germ cell layers: ectoderm, mesoderm, endoderm
  • Cystic to solid (or a mix of both)
  • Malignant transformation is possible (SCC is the most common)
  • Rokitansky nodules: usually where bone, teeth, and hair are found
  • Not associated with any fetal complication or anomalies

GPR19-38 -Fetus papyraceus.tif


Fetus Papyraceous

  • Vanishing twin
  • Intrauterine death of one fetus in a multi-gestational pregnancy
  • Resorbed into the placenta
  • Pale yellow, flattened disk or plaque on the membranes or placental disc
  • May see a pigmented macule (eyes)
  • Skeletal components visible on x-ray

GPR19-38 -Chorangioma.tif



  • Most common placental tumor
  • Single or multiple well-circumscribed ovoid nodules ranging in size
  • Red-brown to tan-white
  • Subchorionic or marginal
  • Hamartoma-like growth of capillaries in the placenta
  • > 1 cm can be a/w FGR/IUGR, preterm delivery, hydrops fetalis, stillbirth

GPR19-38 -Placental IMT.jpg


Inflammatory Myofibroblastic Tumor

  • Neoplasm of intermediate malignant potential
  • Fleshy and circumscribed, solid or cystic nodule attached to the maternal surface
  • Tan, white, or pink with myxoid features
  • Whorled cut surface
  • Thought to arise from the uterus and extend to the placenta
Dr. Drucilla Roberts
Dr. Drucilla Roberts


Pathology Outlines

This week's Gross Pathology Roundup was presented by Bianca Christensen, MD on Mon, Nov 18, 2019.