GPR: 2020 - Week 02
|
|
Nodular Lymphoid Hyperplasia (Terminal Ileum)
- Granular, round-shaped nodules normally between 2 and 10 mm in diameter, distributed along the GI tract - More common in children than in adults - Benign but associated with immunodeficiency (CVID, IgA deficiency) and infection (HIV, Giardia, H. Pylori) |
|
|
Adenoma -Can be pedunculated, sessile, flat or depressed
-Firmness, ulceration or depression suggest progression/invasion -More common in colon than in the small intestine |
|
|
Pseudopolyps - Inflamed projections of regenerative mucosa; may impart cobblestone appearance
- Arise in a background of repeated inflammation/ulceration; inflammatory bowel disease - Presence of pseudopolyps does not increase risk of colorectal neoplasia |
|
|
Intestinal Lymphoma (DLBCL) (Diffuse Large B-Cell Lymphoma)
- Large, solitary, transmurally invasive mass with hemorrhage/ulceration/necrosis; fleshy, tan appearance ("fish flesh") - GI tract most common extranodal site of DLBCL - Predominantly disease of older adults |
Albuquerque A. Nodular lymphoid hyperplasia in the gastrointestinal tract in adult patients: A review. World J Gastrointest Endosc. 2014;6(11):534–540. doi:10.4253/wjge.v6.i11.534
ExpertPath: Adenoma, Colon (Alexandros D. Polydorides, MD, PhD); Colon Adenoma (Joel K. Greenson, MD; Alexandros D. Polydorides, MD, PhD); Ulcerative Colitis, Colon (Scott R. Owens, MD); Diffuse Large B-Cell Lymphoma (Rhonda K. Yantiss, MD; Scott A. Ely, MD, MPH); Diffuse Large B-Cell Lymphoma, Not Otherwise Specified (L. Jeffrey Medeiros, MD; Francisco Vega, MD, PhD; Roberto N. Miranda, MD)
Mahmoud R, Shah SC, Ten Hove JR et al (2018) No association between pseudopolyps and colorectal neoplasia in patients with inflammatory bowel diseases. Gastroenterology. https://doi.org/10.1053/j.gastro.2018.11.067This week's Gross Pathology Roundup was presented by Jakob Moran, MD on Mon, Jan 06, 2020.
