GPR: 2019 - Week 40

From MGH Learn Pathology

Clinical history

A 56 year old woman with a 2 week history of abdominal pain. A CT scan showed a large right retroperitoneal mass.

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Dedifferentiated Liposarcoma
  • Middle-aged to elderly adults
  • Most common in retroperitoneum and abdominal cavity
  • Well circumscribed tan to yellow, firm cut surface (Lipogenic component)
  • Dedifferentiated: fibrous or fleshy (nonlipogenic)

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  • Multinodular growth or solitary mass
  • Gelatinous cut surface
  • Most common in patients 50-70 years of age
  • Often arises superficially in the subcutaneous tissue or dermis
  • Extremely rare in retroperitoneum

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Myxoid Liposarcoma

  • Gelatinous cut surface; more cellular areas often more firm and gray-white
  • Young to middle-aged adults (usually 20-50 years)
  • Deep soft tissue of extremities
  • Majority of cases arise within musculature of thigh
  • Exceptionally rare in retroperitoneum

This week's Gross Pathology Roundup was presented by Michael Gerino Astudillo, MD on Mon, Sep 30, 2019.