GPR: 2019 - Week 23

From MGH Learn Pathology

Clinical history

  • 67 year old man with a 4.3 cm subcutaneous mass along the medial aspect of the ankle/heel
  • The mass has been present 20+ years but recently growing


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Schwannoma
General
  • Nodular with smooth contours
  • Encapsulated
  • Grows eccentrically to nerve of origin
  • Cystic change with hemorrhage and necrosis is common
 

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Neurofibroma

General
  • Most common peripheral nerve sheath tumor
  • Circumscribed but not encapsulated
  • Variable white-tan cut surface
  • Usually lack cystic or hemorrhagic changes
  • Softer consistency than schwannoma
 

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MPNST

General
  • Fusiform enlargement of associated nerve
  • Irregular borders with surrounding tissue
  • Necrosis/hemorrhage is common
 

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Leiomyoma

General
  • Leiomyomas of deep soft tissue are rare
  • Well-circumscribed
  • Gray/white firm cut surface
  • Can have gelatinous/myxoid foci
  • Necrosis is rare
 
Emilio Madrigal, DO
  • Chalidis and Dimitriou, World J Surg Oncol, 2007

This week's Gross Pathology Roundup was presented by Daniel Shepherd, MD, PhD on Mon, Jun 03, 2019.