GPR: 2019 - Week 23

• GPR Quiz
• Answer
• DDx1
• DDx2
• DDx3
• Acknowledgments
• Reference(s)

Clinical history

• 67 year old man with a 4.3 cm subcutaneous mass along the medial aspect of the ankle/heel
• The mass has been present 20+ years but recently growing

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Schwannoma General Nodular with smooth contours Encapsulated Grows eccentrically to nerve of origin Cystic change with hemorrhage and necrosis is common

Neurofibroma General Most common peripheral nerve sheath tumor Circumscribed but not encapsulated Variable white-tan cut surface Usually lack cystic or hemorrhagic changes Softer consistency than schwannoma

MPNST General Fusiform enlargement of associated nerve Irregular borders with surrounding tissue Necrosis/hemorrhage is common

Leiomyoma General Leiomyomas of deep soft tissue are rare Well-circumscribed Gray/white firm cut surface Can have gelatinous/myxoid foci Necrosis is rare

Emilio Madrigal, DO

• Chalidis and Dimitriou, World J Surg Oncol, 2007

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This week's Gross Pathology Roundup was presented by Daniel Shepherd, MD, PhD on Mon, Jun 03, 2019.