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Clinical history
liver tx bx
Diagnosis
Nodular and fibrotic liver, consistent with cirrhosis, with cholestasis and confluent necrosis of several nodules. Note: The liver shows architectural effacement with conversion of the parenchyma into micronodules, essentially a micronodular cirrhosis on Trichrome. Several of the nodules are entirely necrotic or infarcted, accounting for about 10% of the biopsy (less of the tissue is necrotic on permanent sections than on the frozen slide). The nodules also show canalicular cholestasis. No iron or PAS/D positive globules are present. Elastic and reticulin stains were performed to assess whether the fibrous bands were collapse due to necrosis rather than old scarring. While collapse of parenchyma is probably accentuating the appearance of fibrosis, the overall appearance, together with the trichrome, reticulin and elastic stains, suggests cirrhosis.
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