ACUTE TUBULAR INJURY, SEE NOTE. GLOBAL GLOMERULOSCLEROSIS (9%) INTERSTITIAL FIBROSIS AND TUBULAR ATROPHY (20%) MODERATE TO SEVERE ARTERIOSCLEROSIS MODERATE ARTERIOLAR HYALINOSIS
Note:
Histologic section shows a wedge of frozen cortical tissue with about 77 glomeruli, of which 7 are globally sclerotic. Two glomeruli show periglomerular fibrosis while a few glomeruli show segmental wrinkling and ischemic collapse. The remaining glomeruli appear generally unremarkable. Crescents, necrosis and thrombi are not identified. Tubular injury characterized by tubular dilatation and loss of brush borders is present. Interstitial inflammation is minimal. Fibrosis and tubular atrophy affect about 20% of the cortical area. Arteries show moderate intimal fibrosis. Arterioles show hyalinosis. Vasculitis and thrombi are not present.
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Clinical history
donor bx
Diagnosis
KIDNEY (DONOR), WEDGE BIOPSY (FROZEN SECTION): ACUTE TUBULAR INJURY, SEE NOTE. GLOBAL GLOMERULOSCLEROSIS (9%) INTERSTITIAL FIBROSIS AND TUBULAR ATROPHY (20%) MODERATE TO SEVERE ARTERIOSCLEROSIS MODERATE ARTERIOLAR HYALINOSIS Note: Histologic section shows a wedge of frozen cortical tissue with about 77 glomeruli, of which 7 are globally sclerotic. Two glomeruli show periglomerular fibrosis while a few glomeruli show segmental wrinkling and ischemic collapse. The remaining glomeruli appear generally unremarkable. Crescents, necrosis and thrombi are not identified. Tubular injury characterized by tubular dilatation and loss of brush borders is present. Interstitial inflammation is minimal. Fibrosis and tubular atrophy affect about 20% of the cortical area. Arteries show moderate intimal fibrosis. Arterioles show hyalinosis. Vasculitis and thrombi are not present.
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