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Clinical history
Uveal tumor in a 60-year-old man.
Diagnosis
Choroidal melanoma, mixed cell type. Note the mushroom-shape to the mass with the crown of the mushroom created after the tumor expands through Bruch’s membrane. Many tumor cells are epithelioid in appearance, while others are spindle-shaped, giving the designation mixed cell type uveal melanoma. The tumor extends to the optic nerve head but does not invade it. There is substantial serous fluid under the retina (a nonrhegmatogenous retinal detachment). The tumor cells express both SOX10 and MART1. The PAS stain highlights drusen of Bruch’s membrane near the tumor, as well as some corpora amylacea of the optic nerve. KEY WORDS: uveal melanoma, choroidal melanoma, serous retinal detachment.
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